Comparison of Streptomyces albus muramidase-extracted streptococcal antigen with acid-extracted M antigen and with pepsin-extracted T antigen
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Identification of pemphigus vulgaris antigen extracted from normal human epidermis and comparison with pemphigus foliaceus antigen.
Immunoprecipitations of cultured keratinocyte extracts have shown that pemphigus vulgaris (PV) sera bind a polypeptide of 210,000 mol wt with disulfide-linked chains of 130,000 and 85,000 mol wt. To identify proteins in normal human skin recognized by PV antibodies, we performed immunoprecipitations of normal human epidermal extracts. All 22 PV sera tested immunoprecipitated a complex of polype...
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Streptococcal M proteins are antiphagocytic molecules varying immunologically from type to type while maintaining an identical biological effect. The virulence of the group A streptococcus is directly related to the presence of the M antigens on the cell surface and resistance to infection by these organisms is dependent on the presence of opsonic antibodies directed towards the M molecules. Va...
متن کاملPurification and properties of M protein extracted from group A streptococci with pepsin: covalent structure of the amino terminal region of type 24 M antigen
M protein was extracted from type 24, group A streptococci with pepsin at pH 5.8 and was further purified by ammonium sulfate precipitation, ribonuclease digestion, ion-exchange chromatography, and isoelectric focusing. The purified pepsin extract of M (pep M) protein was shown to be free of nontype-specific immunoreactivity in (a) complement fixation tests with heterologous M antiserum, (b) sk...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1977
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.16.1.310-317.1977